The Hitch-Hiker is a 1953 film noir directed by Ida Lupino, about two fishing buddies who pick up a mysterious hitchhiker during a trip to Mexico. Inspired by the crime spree of the psychopathic murderer Billy Cook (1928–1952), the screenplay was written by Robert L. Joseph, Lupino, and her former husband Collier Young, based on a story by blacklisted Out of the Past screenwriter Daniel Mainwaring (who did not receive screen credit).

The Hitch-Hiker is regarded as the first American mainstream film noir directed by a woman and was selected in 1998 for preservation in the United States National Film Registry as being “culturally, historically or aesthetically significant.”